Solve Professor Moreau’s ruins by following the gargoyle-paw portal logic, then unlock the mutations system without trial-and-error wandering. Keep a manual save before irreversible decisions, and check your version if a game option has changed.
In Professor Moreau’s ruin, activate the entrance mechanism, defeat the animated gargoyle, take its paw and place it on the statue pedestal. Choose the portals the central statue is looking toward. A walkthrough commonly describes the path as eastern → northern → northwestern as you reach higher levels. The mutation system unlocks after you complete the laboratory investigation.
Make it simple
Use this small tool to track progress, make the choice or compare values without leaving the page.
Follow these easy steps
Start the mutation quest
Use the letter from Yennefer in Blood and Wine to begin Turn and Face the Strange and follow the quest marker to the submerged ruin.
Open the first chamber
Inspect the mechanism and use the in-game crossbow interaction on the four marked stone switches when prompted.
Activate the central statue
After the animated gargoyle encounter, collect its paw and put it onto the correct pedestal in the main chamber.
Follow the statue’s gaze
Use the statue as your navigation rule as you climb levels. If a portal takes you back, reconsider which direction the statue faces from your current floor.
Investigate the lab
Search the laboratory, recover the missing megascope components and continue Professor Moreau’s journal/objective sequence.
Unlock mutations
Finish the laboratory research and return to your character panel. Mutation choices and extra slots depend on subsequent investment.
Frequently asked questions
Are there eight gargoyle crystals to activate?
No. The first door has four shootable stone switches, and the portal puzzle uses a gargoyle paw plus a facing-statue clue.
What if I enter the wrong portal?
It returns you to an earlier position, so follow the direction the statue is looking on your current level.
Are four extra skill slots free immediately?
No. Additional slots are unlocked through progressing the mutation system.
References
For readers who want to verify specific mechanics, quests or official announcements.